Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

After encountering this book, you will never look at the tiniest sliver of your own backyard or neighborhood park the same way; instead, you will be stunned by the unexpected variety of species found in an area so small.

Of Minds and Molecules is the first anthology devoted exclusively to work in the philosophy of chemistry. The essays, written by both chemists and philosophers, adopt distinctive philosophical perspectives on chemistry and collectively offer both a conceptualization of and a justification for this emerging field.

The essays, written by both chemists and philosophers, adopt distinctive philosophical perspectives on chemistry and collectively offer both a conceptualization ...

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

The deeper teachings of yoga state that "We are a soul, and have a body," but how do yogis respond when confronted with death-with their own time of passing? In Transitioning in Grace (based on the teachings of Paramhansa Yogananda, author of the classic Autobiography of a Yogi), Nalini Graeber presents true accounts of how longtime yogis and meditators have left their bodies. Some struggled with pain or illness. Others passed suddenly or unexpectedly. Most of these accounts are inspiring; (...) all have something to teach about the transitioning experience. More than just a collection of uplifting stories, this work can serve as a handbook for individuals helping family or friends to leave this world-for those soon to make the transition themselves-and for all thoughtful souls who recognize the wisdom of gaining important insights into early preparation for "Life's Final Exam." Included in these pages: How to prepare for death. A yogic "astral ascension" ceremony (funeral/memorial service) that can be adapted for your particular needs. A description, by a great master of yoga, of what we experience during the moments when we leave our bodies. A simple meditation technique that can help greatly to bring calmness to the event. Stories, descriptions, and poems that offer helpful insights and inspiration. (shrink)

Due to the rapid changes in the medical world and the aging population, the need for advanced care planning grows. Despite efforts to make this topic discussed, only a minority of patients discusses the advance directive with their general practitioner. This study aimed to map thresholds: What barriers are identified by GPs and patients in preparing and discussing an advance directive? A cross section survey in patients and GP’s was performed. Citizens were recruited by multimedia and by street interviews. GP’s (...) were recruited by mailing. Most of the 502 citizens already heard of an advance directive but only 17 had declared one while 21 never want one. Eighty percent wants to take the initiative themselves but half of the participants wants the GP to be actively involved. Thirty percent finds the document too difficult to understand. The need to draw an advance directive grew with increasing age. Of the 117 GP’s involved, 65% drafted five or less advance directives the past year. A lack of time, experience and a poor access to the correct administrative requirements were only a few of the barriers. Preparing and drafting an advance directive is a time-consuming and difficult procedure. Patients and GP’s have the right to be informed and instructed on how to prepare an advance directive. (shrink)

Facial expressions have communicative properties that bear some importance to perceivers. Such expressions are informative with respect to the future behavior of the expressing individual and with respect to the conditions of the broader social environment. This article argues that appropriate responses to facial expressions are an important means by which people adapt to their social ecology. The immediate responses to facial expressions depend on contextual factors. It is more important for individuals to adapt to the ingroup than to other (...) groups, for this reason people should exhibit special sensitivity to ingroup facial expressions. It reviews the literature regarding the role of context in the recognition of facial expressions and regarding group membership and emotion recognition, with a special emphasis on the role of culture. It focuses on facial expressions of emotion if only because of available empirical literature. (shrink)

Minds Without Fear is an intellectual and cultural history of India during the period of British occupation. It demonstrates that this was a period of renaissance in India in which philosophy--both in the public sphere and in the Indian universities--played a central role in the emergence of a distinctively Indian modernity. The book is also a history of Indian philosophy. It demonstrates how the development of a secular philosophical voice facilitated the construction of modern Indian society and the consolidation of (...) the nationalist movement. (shrink)

This book publishes, for the first time in decades, and in many cases, for the first time in a readily accessible edition, English language philosophical literature written in India during the period of British rule.

The Book Presents The Practical Side Of Hindu Philosophy As Manifested In The Different Religiouns Systems Of The Hindus. It Shows The Essential Connection Between Theory And Practice, And To Point Out The True Significance Of The Course Of Discipline Prescribed By The Different Religious Systems For The Attainment Of Spiritual Realisation. A Highly Inteteresting And Important Work To The Literature Of Hindu Thought And Religion. Condition Good.

Baumard et al. make a good case that a sense of fairness evolved and that showing this requires reciprocity games with choice of partner. However, they oversimplify both morality and the evolution of morality. Where fairness is involved in morality, other things are, too, and fairness is often not involved. In the evolution of morality, other things played a role. Plus, the motive for being fair originally was self-interest, not anything moral.

Despite the currently perceived urgent need among contemporary philosophers of chemistry for adjudicating between two rival metaphysical conceptual frameworks—is chemistry primarily a science of substances or processes?—this essay argues that neither provides us with what we need in our attempts to explain and comprehend chemical operations and phenomena. First, I show the concept of a chemical property can survive the abandoning of the metaphysical framework of substance. While this abandonment means that we will need to give up essential properties, contingent (...) properties can give us all the stability we need to account for chemical continuity as well as change. I then go on to show that this attention to clusters of contingent properties does not force us into the arms of an alternative process metaphysical framework either. Finally, I sketch a view I call particularism with respect to chemical properties on analogy with moral particularism. I conclude by sketching some of the implications for the field of philosophy of chemistry of my proposal that we abandon our interest in the metaphysical question of what chemistry is primarily about in favor of a broadly scientific particularism with respect to kinds and properties. (shrink)

Abstract:Subject As Freedom (1930) is correctly regarded as Krishnachandra Bhattacharyya's magnum opus. But this text relies on a set of ideas and develops from a set of concerns that KCB develops more explicitly in essays written both before and after that text, which might be regarded as its intellectual bookends. These ideas are important and fascinating in their own right. They also illuminate KCB's engagement with Kant and with the Vedānta tradition as well as his understanding of freedom itself, including (...) its soteriological dimension. These two essays are "Sankara's Doctrine of Māyā" (1930) and "The Advaita and Its Spiritual Significance" (1936). We explore KCB's conception of philosophy and its relation to spiritual practice through a close reading of these two essays. (shrink)

Very few studies have looked upon the construct of workplace spirituality in sales organization context. This paper integrates workplace spirituality with sales literature. The paper points out that self-interest transcendence is a common aspect in the workplace spirituality concept which emerged a decade ago and in most of the relationship-oriented selling characteristics—customer orientation, adaptability, service orientation, and ethical selling behavior. Based on the common aspect of self-interest transcendence, we propose that workplace spirituality could be a causal precursor to relationship-oriented selling (...) characteristics. We present guidelines for future research, implications for practice and a few potential downsides of workplace spirituality in sales organization. (shrink)

Spirituality is a hot topic of research in recent times in management arena. Though the organizational researchers have intensely started exploring this area, the studies related to selling organizations are few, and fewer are the studies related to selling organizations with individual as the unit of theory. The present study explores the relationship between ‘individual spirituality at work’ and sales professionals’ ‘job satisfaction’, ‘propensity to leave’ and ‘job commitment’. This work focuses on sales professionals across various industries. A cross-sectional survey (...) method is adopted. Correlation analysis is done to reveal the hypothesized relationships. The results reveal that sales professionals’ spirituality at work is positively related to job satisfaction and job commitment, and negatively related to propensity to leave. The results provide the relevance of spirituality at work to salespeople. The selling organizations can also utilize the information and promote the individual expression of spirituality at work. (shrink)

Canonical texts -- Philosophy -- Literature and History.

India has been independent for 70 years now, and it is a good time to reflect on the political philosophy that underwrote the movement that gained that independence. When we do so, we discover the origins of a political vocabulary that is still in use today, although sadly not used with the same rigor and precision with which it was used then. We also find that those who recur to Indian political thought from the pre-independence period tend to return to (...) a single strand of that thought—the theorization of ahimsa by Mohandas K. Gandhi, as for instance in the recent essay on Indian political thought in The New York Times by Gopalkrishna Gandhi (Gandhi won’t leave India 2017). In this discussion, we hope to draw attention to some of the less well-known resources offered by pre-independence Indian philosophy and in particular the political thought of the Arya samaji Congressman, philosopher and political activist, Lajpat Rai. His political philosophy is important for understanding the theorization of and debates within the Indian independence movement; we think that it also suggests ways to think about contemporary political and revolutionary movements and merits consideration in current debates in political philosophy. (shrink)

In this essay I first articulate what I take to be an influential and for the most part persuasive model in the western psychoanalytic tradition that is a response to tragic loss, namely, the one that we find in Freud’s little essay entitled ‘Mourning and Melancholia’ (1917). I then use a well-known Buddhist folk tale about the plight of a young woman named Kisagotami to underscore central elements from Buddhist psychology on the subject of suffering that is a consequence of (...) the loss of a young mother’s only child. Fortified by both traditions, I gather together the ingredients for a cross-cultural mental model that serves to explain and to justify as healthy a specific kind of response to a specific form of suffering, namely, the loss of ones’ loved one. I arrive at this model by asking a number of specific questions of both traditions. For instance, what constitutes a non-pathological response to this kind of suffering? What state of mind represents the cessation of such suffering? Is preoccupation with the dead beloved a way of escaping the fact that the person is dead? Is this a form of ignorance that needs to be removed? Is it a form of moral deficiency? Might certain forms and contexts of ignorance, in effect, put one on a path to enlightenment? (shrink)

The period of British colonial rule in India is typically regarded as philosophically sterile. Indian philosophy written in English during the British colonial period is often ignored in histories of Indian philosophy, or, when considered explicitly, dismissed either as uncreative or as inauthentic. The late Daya Krishna thought hard about this at the end of his life, and we have been thinking about this in conversation with him. We show that this dismissal is unjustified and that this is a fertile (...) period for Indian philosophy in which traditional Indian philosophical ideas were brought into dialogue with the West and advanced with great acumen. In this paper, we present one case study to illustrate this point. (shrink)

Daya Krishna was easily the most creative and original Indian philosopher of the second half of the 20th century. His thought and philosophical energy dominated academic Indian philosophy and determined the nature of the engagement of Indian philosophy with Western philosophy during that period. He passed away recently, leaving behind an enormous corpus of published work on a wide range of philosophical topics, as well as a great deal of incomplete, nearly-complete and complete-but-as-yet-unpublished work. Daya Krishna's thought and publications address (...) a broad range of philosophical issues, including issues of global philosophical importance that transcend considerations of particular traditions; issues particular to Indian philosophy; and issues at the intersection of Indian and Western philosophy, especially questions about the philosophy of language and ontology that emerge in the context of his Samvada project that brought together Western philosophers and Nyaya pandits to discuss questions in the philosophy of language and metaphysics. The volume editors have organized the volume as a set of ten couplets and triplets. Each draws together papers from different periods in Daya Krishna's life: some take different approaches to the same problem or text; in some cases, the second paper references and takes issue with arguments developed in the first; in still others, Daya Krishna addresses very different topics, but using the same distinctive philosophical methodology. Each set is introduced by one of the editors. These couplets are framed by two of Daya Krishna's finest metaphilosophical essays, one that introduces his approach, and one that draws some of his grand morals about the discipline. Daya Krishna's daughter, Professor Shail Mayaram of the Center for the Study of Developing Societies contributes a preface, and Professor Arindam Chakrabarti, a longtime colleague of Daya Krisha and a collaborator on some of his most important philosophical ventures has written the introduction. (shrink)

My dissertation project addresses the problem of the legitimacy of "transcendental" arguments. This is an old, familiar problem that goes all the way back to Kant and The Critique of Pure Reason. There, for the first time, we have an explicit attempt to define, characterize and develop a distinct kind of argument. This kind of argument was intended to provide a model which could be used to establish the truth of a quite distinctive sort of proposition, the synthetic apriori. ;The (...) task of this dissertation is to articulate a central paradigm for transcendental arguments, that of being a conceivability argument of a rather special kind; and to reconstruct a Davidsonian argument in the philosophy of language that has all the features that are essential to the paradigm and to show that this argument avoids the familiar sorts of problem that have been claimed to attach to transcendental arguments in general. The project, if successful, serves to illuminate the kinds of features that we ought to care about in constructing and evaluating transcendental arguments. This dissertation suggests that we need to think of the nature of the transcendental in a way that is different from how it is normally understood, but which is such that it retains what is and has always been the truly deep and substantive reasons for interest in arguments of this kind. (shrink)

This paper is an update of the documents we have concerning the Acts of the Christian martyrs, focused on three main aspects: 1) the kind of acts we know of and their classification from the point of view of their historic value; 2) the versions or editions of the texts that are most accepted by scholars; 3) the relevance of the different parts that make up these documents in order to discern the original text from passages that were rewritten or (...) underwent later variations. In this way, the article offers an exhaustive list of the documents for use in researching Christian martyrs in the Roman period. (shrink)

Ethical selling has been found to have significant influence on sales performance and relational selling behaviors. However, sales ethics was mostly explored through a negative lens and we depart from this tradition by using a positive lens. Using broaden-and-build theory, this paper examines the influence of flow on ethical selling. The mediating role of information sharing is also examined. Results from a study of 192 pharmaceutical salespeople in India suggest that flow influences ethical selling behavior via information sharing. The findings (...) imply that flow can serve as a driver for information sharing and ethical decision making among salespeople. The study contributes to the sales ethics literature by extending the application of positive psychology to the sales domain for the first time. (shrink)